The effect of progressive sarcoma 180 growth upon the uterotrophic response to estrogen in mice.

The uterotrophic responses to various doses of estradiol benzoate, estrone, and estriol were investigated in ovariectomized Sarcoma 180-bearing mice at different stages of tumor growth. The data indicate that the uterine response was decreased as tumor growth progressed when compared with that of the tumor-free ovariectomized control animals. Restricting food intake by pair-feeding did not alter the uterine response to estradiol benzoate in the tumor-free animals but did diminish the estrogen induced uterine growth in tumor-bearing animals.